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Meningioma

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Meningioma Classification and external resources
A contrast enhanced CT scan of the brain, demonstrating the appearance of a Meningioma.
ICD-10	C70, D32
ICD-9	225.2
ICD-O:	9530
OMIM	607174
DiseasesDB	8008
eMedicine	neuro/209 radio/439
MeSH	D008579

Meningiomas are the most common primary tumor of the central nervous system, arising from the arachnoid "cap" cells of the arachnoid villi in the meninges.^[1] These tumours are usually benign in nature; however, they can be malignant.^[2]

Contents 1 Causes 2 Signs and symptoms 3 Mechanism 4 Diagnosis 5 Treatment 5.1 Observation 5.2 Surgical resection 5.3 Radiation therapy 5.4 Conventional chemotherapy 6 See also 7 References 8 External links

Causes

Most cases are sporadic while some are familial. Persons who have undergone radiation to the scalp are more at risk for developing meningiomas.^[3]

The most frequent genetic mutations involved in meningiomas are inactivation mutations in the neurofibromatosis 2 gene (merlin) on chromosome 22q. Other possible genes/loci include: MN1^[4] PTEN^[5] an unknown gene at 1p13^[6]